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CD8+ and CD4+ T, NK, NKT, B cells, macrophages, and monocytes, are lower in MYCN -A- than in MYCN -NA tumors ( MYCN -NA tumors had significantly higher cytotoxic TIL signatures than MYCN -A tumors ( MYCN silencing in NB cell lines enhances IFN- activity, promotes Th1-recruiting chemokines (CXCL9 and CXCL10), increases T cell infiltration (63)

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