Phthalimidinoglutarimide-C3-O-PEG1-OH protac precursor 85 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCCN=[N]#N)C3=CC=CC=C3C2(C)C)N(CCCS([O-])(=O)=O)C2=CC=CC=C12 Purity (HPLC):

85 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCCN=[N]#N)C3=CC=CC=C3C2(C)C)N(CCCS([O-])(=O)=O)C2=CC=CC=C12 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

355 SMILES OC(=O)CCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

57 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCCN=[N]#N)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

352 SMILES: NC1=CC=C2C(OC3=CC(=[NH2+])C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(O)=O)=C1

Product Name Thalidomide-propargyl-O-PEG5-OH Synonyms Thalidomide-4'-propargyl-O-PEG5-OH CAS Number n/a Related CAS Molecular Formula C26H32N2O10 Molecular Weight 532

Phthalimidinoglutarimide-C3-O-PEG1-OH protac precursor 85 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCCN=[N]#N)C3=CC=CC=C3C2(C)C)N(CCCS([O-])(=O)=O)C2=CC=CC=C12 Purity (HPLC):Degrader building block for targeted protein degradation. Contains an E3 ligase ligand with a linker and a function group, which can be conjugated to target protein ligands through straightforward chemical reactions. Product Name Phthalimidinoglutarimide C3 O PEG1 OH Synonyms Phthalimidinoglutarimide 4' C3 O PEG1 OH CAS Number n a Related CAS Molecular Formula C18H22N2O5 Molecular Weight 346. 383 SMILES OCCOCCCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1