Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG4) Size:50mg 653 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)

653 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

124 Purity (HPLC) >= 95% Solubility DMSO

with a Kd value of 69 nM towards DCAF1 measured by fluorescence polarization

making it a powerful tool for monitoring SARM1 activation in biochemical assays

Product Name Thalidomide-O-acetamido-C3-amine HCl Synonyms Thalidomide-4'-O-acetamido-C3-amine HCl CAS Number 2565805-08-3 Related CAS 2022182-57-4 (free base) Molecular Formula C18H21ClN4O6 Molecular Weight 424

Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG4) Size:50mg 653 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived