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TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4
Biotin is a high-affinity ligand for streptavidin and avidin proteins
241 Purity (HPLC) >= 95% Solubility DMSO
dCeMM1 is a glue degrader of RBM39 that functions by re-directing the activity of the CRL4DCAF15 ligase
Berishvili
DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8)-PNP Size:10mg TMX-4100 shows a high degradationSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine
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