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The succinyl group mimics a biologically relevant post-translational modification (lysine succinylation)
Product Name Lenalidomide-CO-C3-acid Synonyms Lenalidomide-4'-CO-C3-acid CAS Number 1334496-37-5 Related CAS Molecular Formula C18H19N3O6 Molecular Weight 373
This modification makes it non-fluorescent in its initial state (a "pro-fluorophore")
Building Block for DACF1 Binders and PROTACs based on DACF1 Binders
Product Name: Thalidomide-O-C5-amine Synonyms: 1H-
DBCO-Dap(m-PEG4)-Val-Ala-PAB dbco-dap-m-PEG4 The succinyl group mimics aSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,
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