DBCO-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:25mg 351 SMILES O=C(CCC#C)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

351 SMILES O=C(CCC#C)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Biotin is a high-affinity ligand for streptavidin and avidin proteins

Product Name ethyl 2-(4-nitrophenyl)(d2)acetate Synonyms CAS Number 1376709-86-2 Related CAS Molecular Formula C10H11NO4 Molecular Weight 211

729 Purity (HPLC) >= 95% Solubility DMSO

Product Name DOTA-PEG2-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C22H40N8O9 Molecular Weight 560

DBCO-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:25mg 351 SMILES O=C(CCC#C)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU